10+ Co-Stars Who Became Best Friends (And Those Who Didn't)

Just when your favorite movies or TV shows couldn't get any better, we learn that a lot of celebs found their BFFs on set.

But the opposite can also be true: co-stars really disliking each other. Talk about an awkward workplace environment!

Here are 10+ co-stars who became best friends (and those who didn't).

1. Besties: Courtney Cox and Jennifer Aniston

We can never get enough of their adorable friendship, which started on the set of Friends.

“We just have fun, we laugh, we're inseparable, and it's great," Cox told TV Week. Courteney was even Jen's maid of honor in her wedding to Justin Theroux!

2. Enemies: Blake Lively and Leigton Meester

If you've never seen photographs of these two outside of Gossip Girl, there's a reason for that.

"Blake and Leighton have never been best friends, and never professed to be," Blake's rep once wrote. "Blake goes to work, does her job, and goes home."

3. Besties: Cameron Diaz and Drew Barrymore

While the pair knew each other before Charlie's Angels, it was that filming experience that really cemented their friendship.

Drew called Cameron the most loyal friend. “Not that any one of us are going to jail anytime soon, but 100% she’d get in there and get you out," she told Good Housekeeping.

4. Enemies: Debra Messing and Megan Mullally

They played best friends on Will and Grace for eight seasons and even returned for the show's revival. But rumors has it that these two can't stand each other.

In the midst of these rumors, the pair even unfollowed each other on Instagram.

While on her podcast, Mullally brought up being bullied at her workplace.

Many believed she was referring to Messing.

"I've been bullied — I'm 60 and I'm being bullied right now, so you know it's a very insidious and dangerous thing and I never want to lose that happy and innocent part of myself but it's almost like you have to kill that," she said.

5. Besties: Sophie Turner and Maisie Williams

These two are basically sisters, just like they portrayed on HBO's Game of Thrones.

It was even Sophie who convinced Maisie to take her latest role in The New Mutants. "It’s so wonderful having Sophie as a friend and a voice of reason," Maisie told Grazia Daily.

6. Enemies: Alex Pettyfer and Channing Tatum

It was Alex came out and said that Channing doesn't like him — and that it was his own fault.

He told The Hollywood Reporter that since he was nervous on set, it made him come off as standoffish and arrogant.

Things really hit a breaking point when he rented an apartment that was owned by Tatum's friend.

But since the place apparently had terrible mold and dust, Alex left.

He then forgot to pay four months of back rent since his cousin died. This resulted in an angry email from Channing.

7. Besties: Leonardo DiCaprio and Kate Winslet

Despite their insane chemistry, these Titanic co-stars never pursued a romantic relationship. They did, however, become BFFs!

She even refused to boycott the Oscars in 2016 since she was so sure Leo would win. "[H]e is my closest friend in the world and I just couldn't imagine not being there to support him," she told Vanity Fair.

8. Enemies: William Shatner and George Takei

Their feud has been going on for five decades! In his 1994 autobiography, George wrote that his Star Trek co-star would pretend not to know him on set.

This led George to not invite Shatner to his 2008 wedding.

9. Besties: James Franco and Seth Rogen

These two have been a wacky duo ever since they starred in Freaks and Geeks together. From there, they've done a number of movies together.

In their free time, they hand out. Like the time they spoofed Kanye West's music video with Kim Kardashian.

10. Enemies: Shia Labeouf and Tom Hardy

These two disliked each other so much during filming Lawless that they once got into a physical altercation.

"It escalated to the point where they had to both be restrained," John Hillcoat, the film's director, said in a Reddit AMA.

11. Besties: Ashley Tisdale and Vanessa Hudgens

These two were actually friends way before their High School Musicial days! They first met at a commercial as kids.

Now, as adults, they drink wine together and renovate and decorate each other's houses. Vanessa was even in Ashley's wedding!

12. Enemies: Lucy Liu and Bill Murray

It's a known fact that these two butted heads on Charlie's Angels. At one point, Liu reportedly threw punches when he insulted her acting.

He had complimented Cameron Diaz and Drew Barrymore when he suddenly turned to Liu and said, "what in the hell are you doing here."

13. Besties: Brad Pitt and George Clooney

These two hunks have been besties ever since filming Oceans 11 together all the way back in 2011.

Their friendship is filled with hilarious moments, like the time Brad pranked George by telling everyone on set not to look George in the eye or talk to him.

14. Enemies: Shannen Doherty and Alyssa Milano


They may have played sisters on Charmed, but there was no love lost between these two.

"I can tell you that we were on the air with her for three years and there were definitely some rough days," Milano told Andy Cohen.

15. Besties: Tina Fey and Amy Poehler

They are the very definition of BFF goals! While they knew each other from improv class, it was their time on SNL together that really cemented their friendship.

"She was sharp, shy, and hilarious," Amy wrote in her memoir about Tina.

16. Enemies: Stana Katic and Nathan Fillion

Beacon Pictures

"Stana and Nathan completely despise each other," an insider told Us Weekly, back when the show was still on the air.

Despite this, they made it several seasons having to fake chemistry as a married couple onscreen.

17. Besties: Zach Braff, Donald Faison, Sarah Chock, and Krista Miller

After nine seasons of Scrubs, these co-stars became more like family.

To this day, they post photos of their hangouts on Instagram. This even includes old photos of them when they were younger. Can the show come back pleeeease?