Have you ever been in a room with a bunch of Friends fans? It's basically a battle of favorite quotes, scenes, and character analyses. If you're not big into the show (please, do not come for me), then it feels like an out-of-body dissociated experience. I can guarantee, if you just up and left, no one would know.
With that said, Friends fans are certainly ready with their ammo of trivia, which makes a Friends-themed Guess Who? game perfect for them!